Tsitsipas was stunned by a very aggressive Fritz, who used a bad serving day from Tsitsipas to attack him early in rallies, and the Greek never found a good response.
A 6-2 6-4 win for Fritz left Tsitsipas visibly upset at the way he played, and he lamented that after the match during his press conference.
"I just seemed off. My serve was not working very well today, and against opponents like Taylor, you have to serve well. I was aware of that during the match. I just couldn't find the rhythm."
Despite being aware of his struggles, Tsitsipas failed to adjust accordingly, and Fritz managed to keep the match relatively simple.
Tsitsipas was quite confident before the event that he would be able to make it three in a row, but ultimately he didn't perform up to last year's standard.
"I am much better than this and I'm disappointed I was not able to show my game today. I tried to fight on the second set. It's a good lesson. It's not a happy day for me, but it's a good lesson."
Speaking after the match, the Greek player also confirmed that his shoulder injury is proving quite tricky to manage as it keeps impacting his season.
He famously declared that everything was fine leading up to the ATP Masters 1000 event in Monte-Carlo, but it seems like that might not be the full story.
"This injury on my shoulder didn't really give me the opportunity to build up momentum and rhythm. I have been thinking about it, how I could have gained points playing in Acapulco, perhaps playing healthy in Indian Wells and Miami, and these are the Tour tournaments that I was actually aiming for, because these are big tournaments."
"They can give you a lot of points to add to your confidence and keep building on the Race to Turin, which is important to me."